Medication and Dose Optimization in Extracorporeal Membrane Oxygenation
P: 1-14
March 2024

Medication and Dose Optimization in Extracorporeal Membrane Oxygenation

J Turk Soc Intens Care 2024;22(1):1-14
1. Hacettepe Üniversitesi Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, Ankara, Türkiye
2. Hacettepe Üniversitesi Eczacılık Fakültesi, Ankara, Türkiye
No information available.
No information available
Received Date: 28.11.2023
Accepted Date: 08.02.2024
Publish Date: 07.03.2024


Extracorporeal membrane oxygenation (ECMO) increases circulating volume of distribution, leading to capillary leakage and temporarily altering renal function. Therefore, this may affect pharmacokinetics. In this review, factors affecting pharmacokinetics and pharmacodynamics in veno-arterial and venovenous ECMO, the causes of drug sequestration that may occur in the ECMO circuit, the effects of physicochemical parameters of drugs in the ECMO circuit, and ECMO variable dose optimization have been reviewed from the studies in the current literature. Data reported on the limitations, indications and complications of ECMO are also mentioned. The limited use of ECMO in the coronavirus disease-2019 pandemic, its use in reported cases, and which symptoms it is usually used to support the treatment of are described.

Keywords: Extracorporeal membrane oxygenation, ECMO circuit, drug, pharmacokinetics, pharmacodynamics, dose adjustment


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